Molecular Modelling of Insecticide Binding Sites of the Voltage-Gated Sodium Channels of Fall Armyworm, (Spodoptera frugiperda)

Fall armyworm is a polyphagous migratory pest. Insecticides are used as major components of integrated pest management to control the pest, however, full dependence on insecticides has made evolve resistance most insecticide classes.The involvement ofvoltage-gated sodium channels in excitation cells makes them primary target site large number synthetic and naturally occurring neurotoxins. Consequently, it imperative delineate molecular determinants that mediate interactions between with voltage-gated channels. The present study sought identify residues involved binding these demarcate efficacious depending their affinity took an in-silico approach docking sites along known specific amino acids homology Spodoptera frugiperda was developed predict different insect. current identified acid could enhance effectiveness against fall armyworm. do not also showed this channel, indicating possibility mode action be confirmed by experimental studies. Our findings can direct efforts monitor for mutations result given new interacting were identified. These enable better when develops.